Heritability of mammographic breast density
نویسندگان
چکیده
منابع مشابه
Volumetric mammographic density: heritability and association with breast cancer susceptibility loci.
BACKGROUND Mammographic density is a strong heritable trait, but data on its genetic component are limited to area-based and qualitative measures. We studied the heritability of volumetric mammographic density ascertained by a fully-automated method and the association with breast cancer susceptibility loci. METHODS Heritability of volumetric mammographic density was estimated with a variance...
متن کاملThe heritability of mammographic breast density and circulating sex-hormone levels: two independent breast cancer risk factors.
BACKGROUND Mammographic breast density and endogenous sex-hormone levels are both strong risk factors for breast cancer. This study investigated whether there is evidence for a shared genetic basis between these risk factors. METHODS Using data on 1,286 women from 617 families, we estimated the heritabilities of serum estradiol, testosterone, and sex-hormone binding globulin (SHBG) levels and...
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PURPOSE Mammographic breast density (MBD) is decreased by tamoxifen, but the effect of aromatase inhibitors is less clear. EXPERIMENTAL DESIGN We enrolled early-stage postmenopausal patients with breast cancer initiating adjuvant aromatase inhibitor therapy and ascertained mammograms before and at an average 10 months of aromatase inhibitor therapy. We matched cases to healthy postmenopausal ...
متن کاملRacial differences in mammographic breast density.
BACKGROUND African American women have a lower incidence but a higher mortality from breast carcinoma than Caucasians. A proposed explanation for this discrepancy is the decreased efficacy of screening among African American women. Increased breast density in African American women may result in decreased sensitivity of mammography. The purpose of this article is to determine whether there is a...
متن کاملInvestigating the Factors Affecting the Mammographic Density of Breast Tissue in Patients Referred to the Breast Cancer Research Center, Iran
Introduction: Of the factors leading to false negative results in mammography is breast tissue density, and by increasing the density of breast tissue in mammography, the mammography sensitivity decreases. On the other hand, increasing the breast tissue density leads to increased risk of breast cancer. Various factors such as inheritance, genetics, hormonal and reproductive factors, and nutriti...
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ژورنال
عنوان ژورنال: Quantitative Imaging in Medicine and Surgery
سال: 2020
ISSN: 2223-4292,2223-4306
DOI: 10.21037/qims-2020-20